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Obesity

KCNMA1 · rs2116830

Where this position leads

What the study found

Who was studied 164 European ancestry morbidly obese individuals, 163 European ancestry lean individuals; replicated in 4,674 European ancestry morbidly obese individuals, 5,663 European ancestry lean individuals.

The effect Each copy of the G allele carried 1.26 times the odds of Obesity (95% confidence interval 1.12-1.41); p = 3 × 10⁻¹⁰.

How common The G allele had a frequency of about 80% in the people studied.

Where it sits Chromosome 10, band 10q22.3 — in the 3′ untranslated region of KCNMA1.

What ClinVar records

Classification Benign for Generalized epilepsy-paroxysmal dyskinesia syndrome; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-01-13. ClinVar record 300951 NM_001161352.2(KCNMA1):c.*488C>A

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

G/G Two copies of the version the research linked to Obesity. That is the strongest link of the three results. A link in a study is not a diagnosis.

G/T One copy of the version the research linked to Obesity. That is a smaller link than two copies.

T/T No copy of the version the research linked to Obesity. This is the starting point the study compared everyone against.

Source

Genome wide association study identifies KCNMA1 contributing to human obesity

Jiao H, Arner P, Hoffstedt J, Brodin D, Dubern B, Czernichow S, van't Hooft F, Axelsson T, Pedersen O, Hansen T, Sørensen TI, Hebebrand J

and 5 more — show all

Kere J, Dahlman-Wright K, Hamsten A, Clement K, Dahlman I

BMC medical genomics · 2011 · PMID 21708048 · open access

Questions about rs2116830

What is rs2116830?

rs2116830 is a single position in the genome, in or near the KCNMA1 gene. Published research associates it with obesity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2116830 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs2116830 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2116830 come from?

GWAS Catalog, BMC Med Genomics 2011, PMID:21708048. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Obesity (rs2116830). MyGeneLog™. https://www.mygenelog.com/variants/rs2116830

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