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Familial isolated dilated cardiomyopathy

LMOD2 · rs2116731333

Where this position leads

Condition: Dilated Cardiomyopathy

rs2116731333 Condition: Dilated Cardiomyopathy Dilated Cardiomyopathy Condition rs2116731333 rs2116731333 LMOD2

Strength of the evidence

1 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 0 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Pathogenic for Familial isolated dilated cardiomyopathy, Cardiomyopathy, dilated, 2G; no assertion criteria provided (0 of 4 stars, 2 submitters), last evaluated 2022-05-26. ClinVar record 1328520 NM_207163.3(LMOD2):c.273+1G>A

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version ClinVar lists as disease-causing for Familial isolated dilated cardiomyopathy. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. This call was sent to ClinVar without the lab's criteria, the least certain kind of record, so it may change. (ClinVar VCV001328520, no assertion criteria provided)
A/G One copy of the version ClinVar lists as disease-causing for Familial isolated dilated cardiomyopathy. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. This call was sent to ClinVar without the lab's criteria, the least certain kind of record, so it may change. (ClinVar VCV001328520, no assertion criteria provided)
G/G No copy of the version ClinVar lists as disease-causing for Familial isolated dilated cardiomyopathy. This is the usual result. This call was sent to ClinVar without the lab's criteria, the least certain kind of record, so it may change. (ClinVar VCV001328520, no assertion criteria provided)

Source: ClinVar VCV001328520, no assertion criteria provided

Questions about rs2116731333

What is rs2116731333?

rs2116731333 is a single position in the genome, in or near the LMOD2 gene. Published research associates it with familial isolated dilated cardiomyopathy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2116731333 linked to?

On MyGeneLog this position is linked to Dilated Cardiomyopathy. The research behind each link, and its sources, are set out on that condition page.

Does having rs2116731333 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2116731333 come from?

ClinVar VCV001328520, no assertion criteria provided. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Familial isolated dilated cardiomyopathy (rs2116731333). MyGeneLog™. https://www.mygenelog.com/variants/rs2116731333

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