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Who was studied 129,080 European ancestry cases, 473,524 European ancestry controls; replicated in 462,753 cases, 1,127,474 controls.
The effect
Each copy of the G allele shifted the measure 0.037 lower; p = 1 × 10−10.
How common The G allele had a frequency of about 77% in the people studied.
Where it sits Chromosome 7, band 7q31.33 — in an intron of GRM8.
What each result means
G/GTwo copies of the version the research linked to Gastroesophageal reflux disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Gastroesophageal reflux disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Gastroesophageal reflux disease. This is the starting point the study compared everyone against.
rs2106353 is a single position in the genome, in or near the GRM8 gene. Published research associates it with gastroesophageal reflux disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2106353 linked to?
On MyGeneLog this position is linked to Gastroesophageal Reflux Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs2106353 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2106353 come from?
GWAS Catalog, Gut 2022, PMID:34187846. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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