Standard

Urate levels

MED4 · rs2104480

Where this position leads

Condition: Gout

rs2104480 Condition: Gout Gout Condition rs2104480 rs2104480 MED4

What the study found

Who was studied 342,087 European ancestry individuals, 6,011 African ancestry individuals, 7,328 South Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0203 lower (95% confidence interval 0.015-0.026); p = 2 × 10−13.

Where it sits Chromosome 13, band 13q14.2 — in an intron of MED4-AS1.

What each result means

C/C No copy of the version the research linked to Urate levels. This is the starting point the study compared everyone against.
C/G One copy of the version the research linked to Urate levels. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Urate levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2104480

What is rs2104480?

rs2104480 is a single position in the genome, in or near the MED4 gene. Published research associates it with urate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2104480 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs2104480 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2104480 come from?

GWAS Catalog, Nat Genet 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Urate levels (rs2104480). MyGeneLog™. https://www.mygenelog.com/variants/rs2104480

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