Sensitive

Bipolar disorder lithium response (continuous) or schizophrenia

HLA · rs209474

Where this position leads

What the study found

Who was studied 2,366 European ancestry lithium treated bipolar disorder cases, 220 Asian ancestry lithium treated bipolar disorder cases, 36,989 schizophrenia cases, controls (see Ripke et al 2014 PMID:25056061).

The effect The reported allele is A; the catalogue records no effect size ; p = 2 × 10⁻⁸.

Where it sits Chromosome 6, band 6p21.32 — inside HLA-DMA.

What each result means

A/A Two copies of the version the research linked to Bipolar disorder lithium response (continuous) or schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Bipolar disorder lithium response (continuous) or schizophrenia. That is a smaller link than two copies.

G/G No copy of the version the research linked to Bipolar disorder lithium response (continuous) or schizophrenia. This is the starting point the study compared everyone against.

Source

Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study

Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N

and 100 more — show all

Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Étain B, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy S, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Novák T, O'Donovan C, Ozaki N, Ösby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Volkert J, Witt S, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT

International Consortium on Lithium Genetics (ConLi+Gen)

JAMA psychiatry · 2018 · PMID 29121268

Questions about rs209474

What is rs209474?

rs209474 is a single position in the genome, in or near the HLA gene. Published research associates it with bipolar disorder lithium response (continuous) or schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs209474 linked to?

On MyGeneLog this position is linked to Bipolar Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs209474 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs209474 come from?

GWAS Catalog, JAMA Psychiatry 2017, PMID:29121268. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Bipolar disorder lithium response (continuous) or schizophrenia (rs209474). MyGeneLog™. https://www.mygenelog.com/variants/rs209474

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