Sensitive

Alzheimer's disease or family history of Alzheimer's disease

KALRN · rs2093468087

Where this position leads

Condition: Alzheimer's Disease

rs2093468087 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs2093468087 rs2093468087 KALRN

What the study found

Who was studied 37,075 European, African, Admixed American, Asian, Middle Eastern, Oceanic or unknown ancestry cases, 367,392 European, African, Admixed American, Asian, Middle Eastern, Oceanic or unknown ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 4 × 10−8.

Where it sits Chromosome 3, band 3q21.2 — in an intron of KALRN.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alzheimer's disease or family history of Alzheimer's disease compared to the general population.
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alzheimer's disease or family history of Alzheimer's disease.
T/T Published research associates this genotype with typical/baseline likelihood of Alzheimer's disease or family history of Alzheimer's disease — no copies of the reported risk allele.
Source

Questions about rs2093468087

What is rs2093468087?

rs2093468087 is a single position in the genome, in or near the KALRN gene. Published research associates it with alzheimer's disease or family history of alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2093468087 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs2093468087 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2093468087 come from?

GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2025, PMID:39998322. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease or family history of Alzheimer's disease (rs2093468087). MyGeneLog™. https://www.mygenelog.com/variants/rs2093468087

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