Standard
Risk-taking tendency (4-domain principal component model)
OTX1 · rs2075375
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 315,894 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0185 lower (95% confidence interval 0.013-0.024); p = 1 × 10−12.
How common The T allele had a frequency of about 58% in the people studied.
Where it sits Chromosome 2, band 2p15 — in an intron of OTX1.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Risk-taking tendency (4-domain principal component model) — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Risk-taking tendency (4-domain principal component model).
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Risk-taking tendency (4-domain principal component model) compared to the general population.
Source
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Karlsson Linnér R,
Biroli P,
Kong E,
Meddens SFW,
Wedow R,
Fontana MA,
Lebreton M,
Tino SP,
Abdellaoui A,
Hammerschlag AR,
Nivard MG,
Okbay A
and 80 more — show all
Rietveld CA,
Timshel PN,
Trzaskowski M,
Vlaming R,
Zünd CL,
Bao Y,
Buzdugan L,
Caplin AH,
Chen CY,
Eibich P,
Fontanillas P,
Gonzalez JR,
Joshi PK,
Karhunen V,
Kleinman A,
Levin RZ,
Lill CM,
Meddens GA,
Muntané G,
Sanchez-Roige S,
Rooij FJV,
Taskesen E,
Wu Y,
Zhang F,
Auton A,
Boardman JD,
Clark DW,
Conlin A,
Dolan CC,
Fischbacher U,
Groenen PJF,
Harris KM,
Hasler G,
Hofman A,
Ikram MA,
Jain S,
Karlsson R,
Kessler RC,
Kooyman M,
MacKillop J,
Männikkö M,
Morcillo-Suarez C,
McQueen MB,
Schmidt KM,
Smart MC,
Sutter M,
Thurik AR,
Uitterlinden AG,
White J,
Wit H,
Yang J,
Bertram L,
Boomsma DI,
Esko T,
Fehr E,
Hinds DA,
Johannesson M,
Kumari M,
Laibson D,
Magnusson PKE,
Meyer MN,
Navarro A,
Palmer AA,
Pers TH,
Posthuma D,
Schunk D,
Stein MB,
Svento R,
Tiemeier H,
Timmers PRHJ,
Turley P,
Ursano RJ,
Wagner GG,
Wilson JF,
Gratten J,
Lee JJ,
Cesarini D,
Benjamin DJ,
Koellinger PD,
Beauchamp JP
Nature genetics · 2019 · PMID 30643258
Questions about rs2075375
What is rs2075375?
rs2075375 is a single position in the genome, in or near the OTX1 gene. Published research associates it with risk-taking tendency (4-domain principal component model). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2075375 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2075375 come from?
GWAS Catalog, Nature genetics 2019, PMID:30643258. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Risk-taking tendency (4-domain principal component model) (rs2075375). MyGeneLog™. https://www.mygenelog.com/variants/rs2075375
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