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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 15 Han Chinese ancestry cases, 806 Han Chinese ancestry controls.
The effect
The reported allele is T; the catalogue records no effect size
; p = 5 × 10−12.
How common The T allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of HLA-C.
What each result means
C/CNo copy of the version the research linked to Methazolamide-induced Stevens-Johnson syndrome / toxic epidermal necrolysis. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Methazolamide-induced Stevens-Johnson syndrome / toxic epidermal necrolysis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Methazolamide-induced Stevens-Johnson syndrome / toxic epidermal necrolysis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Journal of the European Academy of Dermatology and Venereology : JEADV · 2022 · PMID 35122707
Questions about rs2074494
What is rs2074494?
rs2074494 is a single position in the genome, in or near the HLA-C gene. Published research associates it with methazolamide-induced stevens-johnson syndrome / toxic epidermal necrolysis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2074494 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2074494 come from?
GWAS Catalog, Journal of the European Academy of Dermatology and Venereology : JEADV 2022, PMID:35122707. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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