DHX58 · rs2074158
Where this position leads
Condition: Coronary Artery Disease
What the study found
Who was studied 88,192 cases, 162,544 controls; replicated in 34,541 cases, 261,984 controls.
The effect Each copy of the T allele shifted the measure 0.0543 lower (95% confidence interval 0.037-0.071); p = 2 × 10−10.
How common The T allele had a frequency of about 82% in the people studied.
Where it sits Chromosome 17, band 17q21.2 — a missense change in DHX58.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2019-01-09.
ClinVar record 1278116 NM_024119.3(DHX58):c.1274A>G (p.Gln425Arg)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2074158 is a single position in the genome, in or near the DHX58 gene. Published research associates it with coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Circ Res 2017, PMID:29212778. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Coronary artery disease (rs2074158). MyGeneLog™. https://www.mygenelog.com/variants/rs2074158