Standard

Estimated glomerular filtration rate (creatinine)

TRAP1 · rs2072379

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 1,004,040 European ancestry individuals, 165,726 East Asian ancestry individuals, 13,842 African American individuals, 13,359 South Asian ancestry individuals, 4,961 Hispanic individuals, 2 individuals; replicated in 417,288 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.00218 lower (95% confidence interval 0.0017-0.0027); p = 5 × 10⁻¹⁶.

How common The T allele had a frequency of about 69% in the people studied.

Where it sits Chromosome 16, band 16p13.3 — in an intron of TRAP1.

What ClinVar records

Classification Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-11-12. ClinVar record 1254950 NM_016292.3(TRAP1):c.330+169G>A

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version the research linked to Estimated glomerular filtration rate (creatinine). This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Estimated glomerular filtration rate (creatinine). That is a smaller link than two copies.

T/T Two copies of the version the research linked to Estimated glomerular filtration rate (creatinine). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals

Stanzick KJ, Li Y, Schlosser P, Gorski M, Wuttke M, Thomas LF, Rasheed H, Rowan BX, Graham SE, Vanderweff BR, Patil SB, Robinson-Cohen C

and 12 more — show all

Gaziano JM, O'Donnell CJ, Willer CJ, Hallan S, Åsvold BO, Gessner A, Hung AM, Pattaro C, Köttgen A, Stark KJ, Heid IM, Winkler TW

VA Million Veteran Program

Nature communications · 2021 · PMID 34272381 · open access

Questions about rs2072379

What is rs2072379?

rs2072379 is a single position in the genome, in or near the TRAP1 gene. Published research associates it with estimated glomerular filtration rate (creatinine). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2072379 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2072379 come from?

GWAS Catalog, Nature communications 2021, PMID:34272381. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Estimated glomerular filtration rate (creatinine) (rs2072379). MyGeneLog™. https://www.mygenelog.com/variants/rs2072379

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