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Who was studied 42,490 European ancestry cases, 773,420 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.167 log odds ratio higher (95% confidence interval 0.12-0.22); p = 3 × 10−10.
Where it sits Chromosome 6, band 6p21.32 — in an intron of PSMB9.
What each result means
C/CTwo copies of the version the research linked to Hashimoto thyroiditis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Hashimoto thyroiditis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Hashimoto thyroiditis. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 42527560 · open access
Questions about rs2071539
What is rs2071539?
rs2071539 is a single position in the genome, in or near the PSMB9 gene. Published research associates it with hashimoto thyroiditis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2071539 linked to?
On MyGeneLog this position is linked to Lymphocytic Thyroiditis (Hashimoto's). The research behind each link, and its sources, are set out on that condition page.
Does having rs2071539 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2071539 come from?
GWAS Catalog, Nature genetics 2026, PMID:42527560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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