2 392232223122Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity3Meta AI2Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others22Total39Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,999 Han Chinese ancestry male individuals; replicated in 1,496 Han Chinese ancestry male individuals.
The effect
Each copy of the G allele shifted the measure 0.13 g/L lower (95% confidence interval 0.11-0.15); p = 4 × 10−72.
How common The G allele had a frequency of about 27% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — in an intron of NOTCH4.
What ClinVar records
ClassificationBenign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2021-05-14.
ClinVar record 1179245NM_004557.4(NOTCH4):c.4757-73T>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the version the research linked to Complement C3 and C4 levels. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Complement C3 and C4 levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Complement C3 and C4 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
PLoS genetics · 2012 · PMID 23028341 · open access
Questions about rs2071278
What is rs2071278?
rs2071278 is a single position in the genome, in or near the HLA-DRA gene. Published research associates it with complement c3 and c4 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2071278 linked to?
On MyGeneLog this position is linked to Complement C3 and C4 Levels. The research behind each link, and its sources, are set out on that condition page.
Does having rs2071278 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2071278 come from?
GWAS Catalog, PLoS Genet 2012, PMID:23028341. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 392232223122Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity3Meta AI2Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others22Total39Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Complement C3 and C4 levels (rs2071278). MyGeneLog™. https://www.mygenelog.com/variants/rs2071278