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Who was studied 30,234 European ancestry cases, 724,172 European ancestry controls.
The effect
Each copy of the A allele carried 1.07 times the odds of Autoimmune thyroid disease; p = 1 × 10−12.
How common The A allele had a frequency of about 39% in the people studied.
Where it sits Chromosome 8, band 8q24.22 — a missense change in TG.
What ClinVar records
ClassificationBenign/Likely benign for Iodotyrosyl coupling defect; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 9 submitters), last evaluated 2026-05-09.
ClinVar record 258993NM_003235.5(TG):c.3935A>G (p.Asp1312Gly)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Autoimmune thyroid disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Autoimmune thyroid disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Autoimmune thyroid disease. This is the starting point the study compared everyone against.
rs2069556 is a single position in the genome, in or near the TG gene. Published research associates it with autoimmune thyroid disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2069556 linked to?
On MyGeneLog this position is linked to Autoimmune Thyroid Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs2069556 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2069556 come from?
GWAS Catalog, Nature 2020, PMID:32581359. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1622111Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others11Total16Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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