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Hypothyroidism

TG · rs2068128

Where this position leads

Condition: Hypothyroidism

rs2068128 Condition: Hypothyroidism Hypothyroidism Condition rs2068128 rs2068128 TG

What the study found

Who was studied 51,194 European ancestry cases, 443,383 European ancestry controls; replicated in 17,002 cases, 178,141 controls.

The effect Each copy of the A allele shifted the measure 0.0682 lower (95% confidence interval 0.052-0.084); p = 2 × 10−16.

Where it sits Chromosome 8, band 8q24.22 — in an intron of TG.

What each result means

A/A Two copies of the version the research linked to Hypothyroidism. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Hypothyroidism. That is a smaller link than two copies.
G/G No copy of the version the research linked to Hypothyroidism. This is the starting point the study compared everyone against.
Source

Questions about rs2068128

What is rs2068128?

rs2068128 is a single position in the genome, in or near the TG gene. Published research associates it with hypothyroidism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2068128 linked to?

On MyGeneLog this position is linked to Hypothyroidism. The research behind each link, and its sources, are set out on that condition page.

Does having rs2068128 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2068128 come from?

GWAS Catalog, iScience 2022, PMID:36093044. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hypothyroidism (rs2068128). MyGeneLog™. https://www.mygenelog.com/variants/rs2068128

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