NOD2 · rs2066844
Where this position leads
Condition: Asthma
What the study found
Who was studied 64,538 European ancestry cases, 239,321 European ancestry controls.
The effect The reported allele is T; the catalogue records no effect size ; p = 3 × 10−9.
How common The T allele had a frequency of about 4% in the people studied.
Where it sits Chromosome 16, band 16q12.1 — a missense change in NOD2.
What ClinVar records
Classification
Conflicting classifications of pathogenicity; association for Yao syndrome, Blau syndrome, Crohn disease, Inflammatory bowel disease 1, Autoinflammatory syndrome and 1 more; criteria provided, conflicting classifications (1 of 4 stars, 16 submitters), last evaluated 2026-02-03.
ClinVar record 4693 NM_001370466.1(NOD2):c.2023C>T (p.Arg675Trp)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2066844 is a single position in the genome, in or near the NOD2 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2020, PMID:32296059. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Asthma (rs2066844). MyGeneLog™. https://www.mygenelog.com/variants/rs2066844