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Alcohol dependence

ADH1B · rs2066702

Where this position leads

Condition: Major Depression and Alcohol Dependence (Comorbid)

rs2066702 Condition: Major Depression and Alcohol Dependence (Comorbid) Major Depression and Alcohol Depend… Condition rs2066702 rs2066702 ADH1B

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Alcohol dependence — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alcohol dependence.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alcohol dependence compared to the general population.
Source
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci
Gelernter J, Kranzler HR, Sherva R, Almasy L, Koesterer R, Smith AH, Anton R, Preuss UW, Ridinger M, Rujescu D, Wodarz N, Zill P
and 2 more — show all
Zhao H, Farrer LA
Molecular psychiatry · 2014 · PMID 24166409

Questions about rs2066702

What is rs2066702?

rs2066702 is a single position in the genome, in or near the ADH1B gene. Published research associates it with alcohol dependence. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2066702 linked to?

On MyGeneLog this position is linked to Major Depression and Alcohol Dependence (Comorbid). The research behind each link, and its sources, are set out on that condition page.

Does having rs2066702 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2066702 come from?

GWAS Catalog, Mol Psychiatry 2014, PMID:24166409. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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