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Phosphatidylcholine_32:0_[M+H]1+/Phosphatidylethanolamine_35:0_[M+H]1+/Phosphatidate_37:1_[M+NH4]1+ levels

NOTCH4 · rs206017

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 13,814 British ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0746 lower (95% confidence interval 0.052-0.098); p = 2 × 10⁻¹⁰.

Where it sits Chromosome 6, band 6p21.32 — in an intron of NOTCH4.

What each result means

A/A No copy of the version the research linked to Phosphatidylcholine_32:0_[M+H]1+/Phosphatidylethanolamine_35:0_[M+H]1+/Phosphatidate_37:1_[M+NH4]1+ levels. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Phosphatidylcholine_32:0_[M+H]1+/Phosphatidylethanolamine_35:0_[M+H]1+/Phosphatidate_37:1_[M+NH4]1+ levels. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Phosphatidylcholine_32:0_[M+H]1+/Phosphatidylethanolamine_35:0_[M+H]1+/Phosphatidate_37:1_[M+NH4]1+ levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci

Harshfield EL, Fauman EB, Stacey D, Paul DS, Ziemek D, Ong RMY, Danesh J, Butterworth AS, Rasheed A, Sattar T, Zameer-Ul-Asar, Saleem I

and 18 more — show all

Hina Z, Ishtiaq U, Qamar N, Mallick NH, Yaqub Z, Saghir T, Rizvi SNH, Memon A, Ishaq M, Rasheed SZ, Memon FU, Jalal A, Abbas S, Frossard P, Saleheen D, Wood AM, Griffin JL, Koulman A

BMC medicine · 2021 · PMID 34503513 · open access

Questions about rs206017

What is rs206017?

rs206017 is a single position in the genome, in or near the NOTCH4 gene. Published research associates it with phosphatidylcholine_32:0_[m+h]1+/phosphatidylethanolamine_35:0_[m+h]1+/phosphatidate_37:1_[m+nh4]1+ levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs206017 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs206017 come from?

GWAS Catalog, BMC medicine 2021, PMID:34503513. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Phosphatidylcholine_32:0_[M+H]1+/Phosphatidylethanolamine_35:0_[M+H]1+/Phosphatidate_37:1_[M+NH4]1+ levels (rs206017). MyGeneLog™. https://www.mygenelog.com/variants/rs206017

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