ZNF536 · rs2053079
Where this position leads
Condition: Schizophrenia
What the study found
Who was studied 32,405 European ancestry cases, 42,221 European ancestry controls, 1,235 European ancestry cases and 1,235 European ancestry controls from 1235 parent-offspring trios, 1,836 East Asian ancestry cases, 3,383 East Asian ancestry controls; replicated in 1,513 European ancestry cases, 66,236 European ancestry controls.
The effect Each copy of the G allele carried 1.07 times the odds of Schizophrenia (95% confidence interval 1.05-1.1); p = 4 × 10−9.
How common The G allele had a frequency of about 23% in the people studied.
Where it sits Chromosome 19, band 19q12 — in an intron of ZNF536.
rs2053079 is a single position in the genome, in or near the ZNF536 gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature 2014, PMID:25056061. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Schizophrenia (rs2053079). MyGeneLog™. https://www.mygenelog.com/variants/rs2053079