0 5122Reads by AI crawlersClaude0ChatGPT0Google · Gemini1Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 215,551 European ancestry individuals, 57,332 African American individuals, 24,743 Hispanic individuals; replicated in Up to 319,677 individuals.
The effect
Each copy of the T allele shifted the measure 0.0208 mg dl-1 higher (95% confidence interval 0.014-0.028); p = 9 × 10−9.
How common The T allele had a frequency of about 87% in the people studied.
Where it sits Chromosome 3, band 3p24.2 — in an intron of THRB.
What each result means
C/CNo copy of the version the research linked to HDL cholesterol. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to HDL cholesterol. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to HDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2018 · PMID 30275531 · open access
Questions about rs2044753
What is rs2044753?
rs2044753 is a single position in the genome, in or near the THRB gene. Published research associates it with hdl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2044753 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs2044753 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2044753 come from?
GWAS Catalog, Nature genetics 2018, PMID:30275531. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 5122Reads by AI crawlersClaude0ChatGPT0Google · Gemini1Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.