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Low density lipoprotein cholesterol levels

EVI5 · rs2027061

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs2027061 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs2027061 rs2027061 EVI5

What the study found

Who was studied 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.034 lower; p = 4 × 10−10.

Where it sits Chromosome 1, band 1p22.1 — in an intron of EVI5.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Low density lipoprotein cholesterol levels compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Low density lipoprotein cholesterol levels.
T/T Published research associates this genotype with typical/baseline likelihood of Low density lipoprotein cholesterol levels — no copies of the reported risk allele.
Source

Questions about rs2027061

What is rs2027061?

rs2027061 is a single position in the genome, in or near the EVI5 gene. Published research associates it with low density lipoprotein cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2027061 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs2027061 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2027061 come from?

GWAS Catalog, Nat Genet 2018, PMID:29507422. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Low density lipoprotein cholesterol levels (rs2027061). MyGeneLog™. https://www.mygenelog.com/variants/rs2027061

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