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Standard

Height

SYNM-AS1 · rs2016873

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−18, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 472,730 East Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.037 higher (95% confidence interval 0.029-0.045); p = 2 × 10−18.

How common The G allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 15, band 15q26.3 — in the 3′ untranslated region of SYNM-AS1.

What ClinVar records

Classification Benign for Growth delay due to insulin-like growth factor I resistance; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-01-13. ClinVar record 317495 NM_000875.5(IGF1R):c.*1087A>G

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-11-09 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

How common each version is

AG
Korean KRGDB
A 94.2% · G 5.8%
Korean Korea4K
A 94.0% · G 6.0%
Japanese ToMMo
A 90.2% · G 9.8%
Vietnamese
A 96.3% · G 3.7%
World gnomAD
A 96.8% · G 3.2%
World 1000 Genomes
A 96.4% · G 3.6%
World TOPMed
A 97.1% · G 2.9%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to Height. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Height. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Quoting this page

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Height (rs2016873). MyGeneLog™. https://www.mygenelog.com/variants/rs2016873

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