0 6123Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others3Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 415 African American or Afro-Caribbean cases, 55,090 African American or Afro-Caribbean controls, 1,634 European ancestry cases, 314,034 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 3.83 lower (95% confidence interval 3.82-3.85); p = 3 × 10−12.
How common The G allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 18, band 18p11.31 — in an intron of LPIN2.
What ClinVar records
ClassificationConflicting classifications of pathogenicity for Majeed syndrome; criteria provided, conflicting classifications (1 of 4 stars, 2 submitters), last evaluated 2025-12-17.
ClinVar record 439865NM_001375808.2(LPIN2):c.2174+10C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the version the research linked to Takes medication for lung cancer?. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Takes medication for lung cancer?. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Takes medication for lung cancer?. That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs201227858
What is rs201227858?
rs201227858 is a single position in the genome, in or near the LPIN2 gene. Published research associates it with takes medication for lung cancer?. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs201227858 linked to?
On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs201227858 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs201227858 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 6123Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others3Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Takes medication for lung cancer? (rs201227858). MyGeneLog™. https://www.mygenelog.com/variants/rs201227858