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Standard

Total cholesterol levels

ZNF148 · rs2011442

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−12, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0124 higher (95% confidence interval 0.0096-0.0152); p = 5 × 10−13.

How common The T allele had a frequency of about 66% in the people studied.

Where it sits Chromosome 3, band 3q21.2 — in an intron of ZNF148.

How common each version is

CT
Korean KRGDB
C 56.2% · T 43.8%
Korean Korea4K
C 56.1% · T 43.9%
Japanese ToMMo
C 59.5% · T 40.5%
World gnomAD
C 31.1% · T 68.8%
World 1000 Genomes
C 36.6% · T 63.4%
World TOPMed
C 30.6% · T 69.4%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Total cholesterol levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Total cholesterol levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Total cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Quoting this page

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Total cholesterol levels (rs2011442). MyGeneLog™. https://www.mygenelog.com/variants/rs2011442

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