Sensitive

Depression

H2BC15 · rs200990

Where this position leads

Condition: Endometriosis and Depression: Shared Genetics

rs200990 Condition: Endometriosis and Depression: Shared Genetics Endometriosis and Depression: Share… Condition rs200990 rs200990 H2BC15

What the study found

Who was studied 688,809 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 6.26 z score higher; p = 4 × 10−10.

Where it sits Chromosome 6, band 6p22.1 — in an intron of H2BC15.

What each result means

G/G No copy of the version the research linked to Depression. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Depression. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Depression. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs200990

What is rs200990?

rs200990 is a single position in the genome, in or near the H2BC15 gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs200990 linked to?

On MyGeneLog this position is linked to Endometriosis and Depression: Shared Genetics. The research behind each link, and its sources, are set out on that condition page.

Does having rs200990 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs200990 come from?

GWAS Catalog, Nature genetics 2018, PMID:29942085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Depression (rs200990). MyGeneLog™. https://www.mygenelog.com/variants/rs200990

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