0 114214Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI4Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others4Total11Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 168,363 European ancestry cases, 1,725,558 European ancestry controls, 21,202 African ancestry cases, 121,670 African ancestry controls, 12,665 East Asian ancestry cases, 245,263 East Asian ancestry controls, 5,116 Hispanic or Latin American cases, 58,719 Hispanic or Latin American controls.
The effect
Each copy of the G allele shifted the measure 0.045 lower (95% confidence interval 0.036-0.054); p = 9 × 10−24.
How common The G allele had a frequency of about 65% in the people studied.
Where it sits Chromosome 1, band 1p36.22 — in an intron of CASZ1.
What each result means
C/CNo copy of the version the research linked to Heart failure. This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to Heart failure. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Heart failure. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs200854839 is a single position in the genome, in or near the CASZ1 gene. Published research associates it with heart failure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs200854839 linked to?
On MyGeneLog this position is linked to Heart Failure. The research behind each link, and its sources, are set out on that condition page.
Does having rs200854839 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs200854839 come from?
GWAS Catalog, Nature genetics 2025, PMID:40195560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 114214Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI4Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others4Total11Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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