Sleep duration
AUTS2 · rs2006810
Where this position leads
Condition: Sleep and Circadian Rhythm
What the study found
Who was studied 91,105 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.028 SD units lower (95% confidence interval 0.018-0.038); p = 4 × 10−9.
How common The T allele had a frequency of about 60% in the people studied.
Where it sits Chromosome 7, band 7q11.22 — in an intron of AUTS2.
What each result means
In the news
2026-04-01 · Portas L, et al., Nature Communications 2026, PMID:41922918
Genetic architecture of sleep in a genome wide association study of device measured sleep traits
Most sleep genetics rests on what people report about their own sleep. This study measured it instead: sleep duration, sleep efficiency, and accelerometer-derived REM and non-REM sleep in 80,013 UK Biobank participants. It found 20 loci, 12 of them not reported before, including genome-wide significant associations for REM and non-REM sleep duration. MEIS1 showed strong opposing effects on REM and non-REM duration. Analysing women and men separately found distinct loci — FOXP2 and NRXN3 in women; LRP1B, NPBWR2 and PABPC4 in men — and Mendelian randomisation supported a link between shorter sleep and higher cardiometabolic risk. The study's MEIS1 position is not in this catalogue; four of its other positions are, including rs2006810 (AUTS2, sleep efficiency) and rs62033400 (FTO, REM sleep duration), which is filed here under body mass index. PMID:41922918.
From our blog
Questions about rs2006810
What is rs2006810?
rs2006810 is a single position in the genome, in or near the AUTS2 gene. Published research associates it with sleep duration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2006810 linked to?
On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.
Does having rs2006810 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2006810 come from?
GWAS Catalog, Nat Commun 2018, PMID:30531941. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
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Sleep duration (rs2006810). MyGeneLog™. https://www.mygenelog.com/variants/rs2006810