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Benign prostatic hyperplasia and lower urinary tract symptoms

HIST1H2BL · rs200476

Where this position leads

Condition: Benign Prostatic Hyperplasia

rs200476 Condition: Benign Prostatic Hyperplasia Benign Prostatic Hyperplasia Condition rs200476 rs200476 HIST1H2BL

What the study found

Who was studied 20,621 European ancestry cases, 280,541 European ancestry controls.

The effect Each copy of the A allele carried 1.14 times the odds of Benign prostatic hyperplasia and lower urinary tract symptoms (95% confidence interval 1.11-1.18); p = 4 × 10−17.

How common The A allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 6, band 6p22.1 — between genes, 6.5 kb from H4C10P.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Benign prostatic hyperplasia and lower urinary tract symptoms compared to the general population.
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Benign prostatic hyperplasia and lower urinary tract symptoms.
T/T Published research associates this genotype with typical/baseline likelihood of Benign prostatic hyperplasia and lower urinary tract symptoms — no copies of the reported risk allele.
Source
Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA
Gudmundsson J, Sigurdsson JK, Stefansdottir L, Agnarsson BA, Isaksson HJ, Stefansson OA, Gudjonsson SA, Gudbjartsson DF, Masson G, Frigge ML, Stacey SN, Sulem P
and 16 more — show all
Halldorsson GH, Tragante V, Holm H, Eyjolfsson GI, Sigurdardottir O, Olafsson I, Jonsson T, Jonsson E, Barkardottir RB, Hilmarsson R, Asselbergs FW, Geirsson G, Thorsteinsdottir U, Rafnar T, Thorleifsson G, Stefansson K
Nature communications · 2018 · PMID 30410027 · open access

Questions about rs200476

What is rs200476?

rs200476 is a single position in the genome, in or near the HIST1H2BL gene. Published research associates it with benign prostatic hyperplasia and lower urinary tract symptoms. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs200476 linked to?

On MyGeneLog this position is linked to Benign Prostatic Hyperplasia. The research behind each link, and its sources, are set out on that condition page.

Does having rs200476 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs200476 come from?

GWAS Catalog, Nat Commun 2018, PMID:30410027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Benign prostatic hyperplasia and lower urinary tract symptoms (rs200476). MyGeneLog™. https://www.mygenelog.com/variants/rs200476

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