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Weight

PLEKHA8 · rs200338891

Where this position leads

Condition: Obesity and Body Weight

rs200338891 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs200338891 rs200338891 PLEKHA8

What the study found

Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0145 lower (95% confidence interval 0.0098-0.0192); p = 2 × 10−9.

Where it sits Chromosome 7, band 7p14.3 — in an intron of PLEKHA8.

What each result means

C/C No copy of the version the research linked to Weight. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Weight. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Weight. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures
Jee YH, Wang Y, Jung KJ, Lee JY, Kimm H, Duan R, Price AL, Martin AR, Kraft P
Nature communications · 2025 · PMID 40436827 · open access

Questions about rs200338891

What is rs200338891?

rs200338891 is a single position in the genome, in or near the PLEKHA8 gene. Published research associates it with weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs200338891 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs200338891 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs200338891 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Weight (rs200338891). MyGeneLog™. https://www.mygenelog.com/variants/rs200338891

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