Sensitive

Ischemic stroke

VPS33B · rs199921354

Where this position leads

Condition: Ischaemic Stroke

What the study found

Who was studied 450 Japanese ancestry cases, 5,774 Japanese ancestry controls.

The effect The reported allele is C; the catalogue records no effect size ; p = 6 × 10⁻⁹.

How common The C allele had a frequency of about 9% in the people studied.

Where it sits Chromosome 15, band 15q26.1 — a missense change in VPS33B.

What ClinVar records

Classification Uncertain significance for Keratoderma-ichthyosis-deafness syndrome, autosomal recessive, Cholestasis, progressive familial intrahepatic, 12, Arthrogryposis, renal dysfunction, and cholestasis 1; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2024-04-05. ClinVar record 2040830 NM_018668.5(VPS33B):c.320G>A (p.Arg107Gln)

What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Ischemic stroke compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Ischemic stroke.

T/T Published research associates this genotype with typical/baseline likelihood of Ischemic stroke — no copies of the reported risk allele.

Source

Identification of nine genes as novel susceptibility loci for early-onset ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage

Yamada Y, Kato K, Oguri M, Horibe H, Fujimaki T, Yasukochi Y, Takeuchi I, Sakuma J

Biomedical reports · 2018 · PMID 29930801 · open access

Questions about rs199921354

What is rs199921354?

rs199921354 is a single position in the genome, in or near the VPS33B gene. Published research associates it with ischemic stroke. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs199921354 linked to?

On MyGeneLog this position is linked to Ischaemic Stroke. The research behind each link, and its sources, are set out on that condition page.

Does having rs199921354 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs199921354 come from?

GWAS Catalog, Biomed Rep 2018, PMID:29930801. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Ischemic stroke (rs199921354). MyGeneLog™. https://www.mygenelog.com/variants/rs199921354

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