Sensitive

Gestational diabetes mellitus

CDKAL1 · rs1997777

Where this position leads

Condition: Gestational Diabetes Mellitus

rs1997777 Condition: Gestational Diabetes Mellitus Gestational Diabetes Mellitus Condition rs1997777 rs1997777 CDKAL1

What the study found

Who was studied 19,445 Finnish ancestry cases, 270,460 Finnish ancestry controls, 19,445 British ancestry cases, 270,460 British ancestry controls, 12,024 Chinese ancestry cases, 67,845 Chinese ancestry controls.

The effect The reported allele is G; the catalogue records no effect size ; p = 1 × 10−12.

Where it sits Chromosome 6, band 6p22.3 — in an intron of CDKAL1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Gestational diabetes mellitus — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Gestational diabetes mellitus.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Gestational diabetes mellitus compared to the general population.
Source

Questions about rs1997777

What is rs1997777?

rs1997777 is a single position in the genome, in or near the CDKAL1 gene. Published research associates it with gestational diabetes mellitus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1997777 linked to?

On MyGeneLog this position is linked to Gestational Diabetes Mellitus. The research behind each link, and its sources, are set out on that condition page.

Does having rs1997777 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1997777 come from?

GWAS Catalog, Frontiers in endocrinology 2026, PMID:42109742. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Gestational diabetes mellitus (rs1997777). MyGeneLog™. https://www.mygenelog.com/variants/rs1997777

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