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Who was studied 270,059 British ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0142 lower (95% confidence interval 0.011-0.018); p = 6 × 10−16.
Where it sits Chromosome 17, band 17q21.31 — in an intron of NSF.
What each result means
C/CTwo copies of the version the research linked to General factor of neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to General factor of neuroticism. That is a smaller link than two copies.
T/TNo copy of the version the research linked to General factor of neuroticism. This is the starting point the study compared everyone against.
Molecular psychiatry · 2020 · PMID 30867560 · open access
Questions about rs199470
What is rs199470?
rs199470 is a single position in the genome, in or near the NSF gene. Published research associates it with general factor of neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs199470 linked to?
On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.
Does having rs199470 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs199470 come from?
GWAS Catalog, Molecular psychiatry 2020, PMID:30867560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
General factor of neuroticism (rs199470). MyGeneLog™. https://www.mygenelog.com/variants/rs199470