Major depressive disorder or hospitalized COVID-19 (pleiotropy)
NSF · rs199457
0 00Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total0Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 65,075 European ancestry MDD cases, 24,274 European ancestry hospitalized COVID-19 cases, 2,294,081 European ancestry controls.
The effect
The reported allele is T; the catalogue records no effect size
; p = 5 × 10−10.
Where it sits Chromosome 17, band 17q21.31 — in an intron of NSF.
What each result means
C/CNo copy of the version the research linked to Major depressive disorder or hospitalized COVID-19 (pleiotropy). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Major depressive disorder or hospitalized COVID-19 (pleiotropy). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Major depressive disorder or hospitalized COVID-19 (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
Frontiers in psychiatry · 2023 · PMID 37426090 · open access
Questions about rs199457
What is rs199457?
rs199457 is a single position in the genome, in or near the NSF gene. Published research associates it with major depressive disorder or hospitalized covid-19 (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs199457 linked to?
On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs199457 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs199457 come from?
GWAS Catalog, Frontiers in psychiatry 2023, PMID:37426090. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 00Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total0Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Major depressive disorder or hospitalized COVID-19 (pleiotropy) (rs199457). MyGeneLog™. https://www.mygenelog.com/variants/rs199457