Gene Knowledge Graph
UTC
Standard

Regional enteritis (PheCode 555.1)

near TTC33 · rs1992660

Where this position leads

Condition: Crohn's Disease

rs1992660 Condition: Crohn's Disease Crohn's Disease Condition rs1992660 rs1992660 near TTC33

What the study found

Who was studied 567 African American or Afro-Caribbean cases, 121,083 African American or Afro-Caribbean controls, 3,402 European ancestry cases, 446,631 European ancestry controls, 236 Hispanic or Latin American cases, 59,514 Hispanic or Latin American controls.

The effect Each copy of the C allele shifted the measure 0.181 lower (95% confidence interval 0.14-0.22); p = 1 × 10−14.

How common The C allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 5, band 5p13.1 — between genes, 97.4 kb from TTC33.

What each result means

C/C Two copies of the version the research linked to Regional enteritis (PheCode 555.1). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Regional enteritis (PheCode 555.1). That is a smaller link than two copies.
T/T No copy of the version the research linked to Regional enteritis (PheCode 555.1). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs1992660

What is rs1992660?

rs1992660 is a single position in the genome, in or near the near TTC33 gene. Published research associates it with regional enteritis (phecode 555.1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1992660 linked to?

On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs1992660 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1992660 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Regional enteritis (PheCode 555.1) (rs1992660). MyGeneLog™. https://www.mygenelog.com/variants/rs1992660

← See all variants