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Who was studied 91,105 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0328 SD units higher (95% confidence interval 0.022-0.044); p = 3 × 10−9.
How common The G allele had a frequency of about 77% in the people studied.
Where it sits Chromosome 17, band 17q21.31 — in an intron of MAPT.
What each result means
A/ANo copy of the version the research linked to Sleep duration. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Sleep duration. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Sleep duration. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2018 · PMID 30531941 · open access
Questions about rs1991556
What is rs1991556?
rs1991556 is a single position in the genome, in or near the STH gene. Published research associates it with sleep duration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1991556 linked to?
On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.
Does having rs1991556 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1991556 come from?
GWAS Catalog, Nat Commun 2018, PMID:30531941. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 2721912327Reads by AI crawlersClaude0ChatGPT2Google · Gemini1Perplexity0Meta AI9Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others7Total27Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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