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General factor of neuroticism

MSRA · rs1986972

Where this position leads

Condition: Neuroticism

rs1986972 Condition: Neuroticism Neuroticism Condition rs1986972 rs1986972 MSRA

What the study found

Who was studied 270,059 British ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0139 lower (95% confidence interval 0.01-0.017); p = 1 × 10−15.

Where it sits Chromosome 8, band 8p23.1 — in an intron of MSRA.

What each result means

A/A No copy of the version the research linked to General factor of neuroticism. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to General factor of neuroticism. That is a smaller link than two copies.
G/G Two copies of the version the research linked to General factor of neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1986972

What is rs1986972?

rs1986972 is a single position in the genome, in or near the MSRA gene. Published research associates it with general factor of neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1986972 linked to?

On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.

Does having rs1986972 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1986972 come from?

GWAS Catalog, Molecular psychiatry 2020, PMID:30867560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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General factor of neuroticism (rs1986972). MyGeneLog™. https://www.mygenelog.com/variants/rs1986972

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