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Lysophosphatidylcholine_20:4_[M+H]1+ levels

MYRF · rs198472

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁹, with 5 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 13,814 British ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.119 lower (95% confidence interval 0.093-0.144); p = 2 × 10⁻¹⁹.

Where it sits Chromosome 11, band 11q12.2 — in an intron of MYRF.

How common each version is

AG

Korean KRGDB

A 77.5% · G 22.5%

Korean Korea4K

A 77.3% · G 22.7%

Korean Korea1K

A 78.9% · G 21.1%

Japanese ToMMo

A 79.7% · G 20.3%

Vietnamese

A 65.7% · G 34.3%

World gnomAD

A 69.6% · G 30.4%

World 1000 Genomes

A 68.5% · G 31.5%

World TOPMed

A 68.2% · G 31.9%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to Lysophosphatidylcholine_20:4_[M+H]1+ levels. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Lysophosphatidylcholine_20:4_[M+H]1+ levels. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Lysophosphatidylcholine_20:4_[M+H]1+ levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci

Harshfield EL, Fauman EB, Stacey D, Paul DS, Ziemek D, Ong RMY, Danesh J, Butterworth AS, Rasheed A, Sattar T, Zameer-Ul-Asar, Saleem I

and 18 more — show all

Hina Z, Ishtiaq U, Qamar N, Mallick NH, Yaqub Z, Saghir T, Rizvi SNH, Memon A, Ishaq M, Rasheed SZ, Memon FU, Jalal A, Abbas S, Frossard P, Saleheen D, Wood AM, Griffin JL, Koulman A

BMC medicine · 2021 · PMID 34503513 · open access

Questions about rs198472

What is rs198472?

rs198472 is a single position in the genome, in or near the MYRF gene. Published research associates it with lysophosphatidylcholine_20:4_[m+h]1+ levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs198472 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs198472 come from?

GWAS Catalog, BMC medicine 2021, PMID:34503513. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Lysophosphatidylcholine_20:4_[M+H]1+ levels (rs198472). MyGeneLog™. https://www.mygenelog.com/variants/rs198472

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