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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 7,069 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.146 higher; p = 2 × 10−12.
Where it sits Chromosome 11, band 11q12.2 — in a non-coding transcript of MYRF.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Phosphatidylcholines (17:0/20:4) (Model 2) compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Phosphatidylcholines (17:0/20:4) (Model 2).
G/GPublished research associates this genotype with typical/baseline likelihood of Phosphatidylcholines (17:0/20:4) (Model 2) — no copies of the reported risk allele.
Nature communications · 2026 · PMID 42069741 · open access
Questions about rs198459
What is rs198459?
rs198459 is a single position in the genome, in or near the MYRF gene. Published research associates it with phosphatidylcholines (17:0/20:4) (model 2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs198459 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs198459 come from?
GWAS Catalog, Nature communications 2026, PMID:42069741. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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