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Depression

DAGLA · rs198457

Where this position leads

Condition: Depression (Self-Reported Symptoms)

rs198457 Condition: Depression (Self-Reported Symptoms) Depression (Self-Reported Symptoms) Condition rs198457 rs198457 DAGLA

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Depression compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Depression.
T/T Published research associates this genotype with typical/baseline likelihood of Depression — no copies of the reported risk allele.
Source
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Howard DM, Adams MJ, Clarke TK, Hafferty JD, Gibson J, Shirali M, Coleman JRI, Hagenaars SP, Ward J, Wigmore EM, Alloza C, Shen X
and 26 more — show all
Barbu MC, Xu EY, Whalley HC, Marioni RE, Porteous DJ, Davies G, Deary IJ, Hemani G, Berger K, Teismann H, Rawal R, Arolt V, Baune BT, Dannlowski U, Domschke K, Tian C, Hinds DA, Trzaskowski M, Byrne EM, Ripke S, Smith DJ, Sullivan PF, Wray NR, Breen G, Lewis CM, McIntosh AM
23andMe Research Team · Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Nature neuroscience · 2019 · PMID 30718901

Questions about rs198457

What is rs198457?

rs198457 is a single position in the genome, in or near the DAGLA gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs198457 linked to?

On MyGeneLog this position is linked to Depression (Self-Reported Symptoms). The research behind each link, and its sources, are set out on that condition page.

Does having rs198457 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs198457 come from?

GWAS Catalog, Nat Neurosci 2019, PMID:30718901. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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