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Who was studied 1,161 European ancestry cases, 4,683 European ancestry controls; replicated in 876 European ancestry cases, 1,890 European ancestry controls.
The effect
Each copy of the G allele carried 1.41 times the odds of Interstitial lung disease (95% confidence interval 1.28-1.56); p = 9 × 10−14.
How common The G allele had a frequency of about 77% in the people studied.
Where it sits Chromosome 17, band 17q21.31 — in an intron of MAPT.
What each result means
A/ANo copy of the version the research linked to Interstitial lung disease. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Interstitial lung disease. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Interstitial lung disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2013 · PMID 23583980 · open access
Questions about rs1981997
What is rs1981997?
rs1981997 is a single position in the genome, in or near the MAPT gene. Published research associates it with interstitial lung disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1981997 linked to?
On MyGeneLog this position is linked to Interstitial Lung Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs1981997 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1981997 come from?
GWAS Catalog, Nat Genet 2013, PMID:23583980. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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