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Ossification of the posterior longitudinal ligament of the spine

CCDC91 · rs1979679

What the study found

Who was studied 1,112 Japanese ancestry cases, 6,810 Japanese ancestry controls; replicated in 548 Japanese ancestry cases, 6,469 Japanese ancestry controls.

The effect Each copy of the T allele carried 1.30 times the odds of Ossification of the posterior longitudinal ligament of the spine (95% confidence interval 1.21-1.40); p = 4 × 10−12.

How common The T allele had a frequency of about 36% in the people studied.

Where it sits Chromosome 12, band 12p11.22 — in an intron of CCDC91.

What each result means

C/C No copy of the version the research linked to Ossification of the posterior longitudinal ligament of the spine. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Ossification of the posterior longitudinal ligament of the spine. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Ossification of the posterior longitudinal ligament of the spine. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1979679

What is rs1979679?

rs1979679 is a single position in the genome, in or near the CCDC91 gene. Published research associates it with ossification of the posterior longitudinal ligament of the spine. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1979679 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1979679 come from?

GWAS Catalog, Nat Genet 2014, PMID:25064007. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Ossification of the posterior longitudinal ligament of the spine (rs1979679). MyGeneLog™. https://www.mygenelog.com/variants/rs1979679

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