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Who was studied 922 European ancestry cases, 1,526 European ancestry controls; replicated in 3,935 European ancestry cases, 5,754 European ancestry controls.
The effect
Each copy of the A allele carried 1.29 times the odds of Restless legs syndrome (95% confidence interval 1.19-1.40); p = 3 × 10−10.
How common The A allele had a frequency of about 16% in the people studied.
Where it sits Chromosome 9, band 9p24.1 — in an intron of PTPRD.
What each result means
A/ATwo copies of the version the research linked to Restless legs syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Restless legs syndrome. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Restless legs syndrome. This is the starting point the study compared everyone against.
PLoS genetics · 2011 · PMID 21779176 · open access
Questions about rs1975197
What is rs1975197?
rs1975197 is a single position in the genome, in or near the PTPRD gene. Published research associates it with restless legs syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1975197 linked to?
On MyGeneLog this position is linked to Restless Legs Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs1975197 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1975197 come from?
GWAS Catalog, PLoS Genet 2011, PMID:21779176. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 39128122221Reads by AI crawlersClaude0ChatGPT1Google · Gemini0Perplexity2Meta AI8Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others21Total39Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Restless legs syndrome (rs1975197). MyGeneLog™. https://www.mygenelog.com/variants/rs1975197