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Random glucose levels

TENT5C-DT · rs1966228

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 7,644 African ancestry individuals, 1,503 Chinese ancestry individuals, 7,407 Indian, Pakistani ancestry individuals, 458,862 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.00323 higher (95% confidence interval 0.0026-0.0039); p = 5 × 10⁻²².

How common The A allele had a frequency of about 74% in the people studied.

Where it sits Chromosome 1, band 1p12 — in an intron of TENT5C-DT.

What each result means

A/A Two copies of the version the research linked to Random glucose levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Random glucose levels. That is a smaller link than two copies.

G/G No copy of the version the research linked to Random glucose levels. This is the starting point the study compared everyone against.

Source

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG, Chen S, Todorov PV, Sharapov S, David A

and 84 more — show all

Marullo L, Mägi R, Rujan RM, Ahlqvist E, Thorleifsson G, Gao Η, Εvangelou Ε, Benyamin B, Scott RA, Isaacs A, Zhao JH, Willems SM, Johnson T, Gieger C, Grallert H, Meisinger C, Müller-Nurasyid M, Strawbridge RJ, Goel A, Rybin D, Albrecht E, Jackson AU, Stringham HM, Corrêa IR Jr, Farber-Eger E, Steinthorsdottir V, Uitterlinden AG, Munroe PB, Brown MJ, Schmidberger J, Holmen O, Thorand B, Hveem K, Wilsgaard T, Mohlke KL, Wang Z, Shmeliov A, den Hoed M, Loos RJF, Kratzer W, Haenle M, Koenig W, Boehm BO, Tan TM, Tomas A, Salem V, Barroso I, Tuomilehto J, Boehnke M, Florez JC, Hamsten A, Watkins H, Njølstad I, Wichmann HE, Caulfield MJ, Khaw KT, van Duijn CM, Hofman A, Wareham NJ, Langenberg C, Whitfield JB, Martin NG, Montgomery G, Scapoli C, Tzoulaki I, Elliott P, Thorsteinsdottir U, Stefansson K, Brittain EL, McCarthy MI, Froguel P, Sexton PM, Wootten D, Groop L, Dupuis J, Meigs JB, Deganutti G, Demirkan A, Pers TH, Reynolds CA, Aulchenko YS, Kaakinen MA, Jones B, Prokopenko I

GWA-PA Consortium · Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC)

Nature genetics · 2023 · PMID 37679419 · open access

Questions about rs1966228

What is rs1966228?

rs1966228 is a single position in the genome, in or near the TENT5C-DT gene. Published research associates it with random glucose levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1966228 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1966228 come from?

GWAS Catalog, Nature genetics 2023, PMID:37679419. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Random glucose levels (rs1966228). MyGeneLog™. https://www.mygenelog.com/variants/rs1966228

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