Who was studied 18,467 European and unknown ancestry cases, 45,264 European and unknown ancestry controls; replicated in 57,347 European and unknown ancestry cases, 219,521 European and unknown ancestry controls.
The effect
Each copy of the G allele carried 1.05 times the odds of Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (95% confidence interval 1.030-1.064); p = 3 × 10−8.
How common The G allele had a frequency of about 52% in the people studied.
Where it sits Chromosome 19, band 19q13.32 — between genes, 0.4 kb from SNRPD2.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) — no copies of the reported risk allele.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease).
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) compared to the general population.
rs1964272 is a single position in the genome, in or near the SNRPD2 gene. Published research associates it with coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1964272 linked to?
On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs1964272 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1964272 come from?
GWAS Catalog, Nat Genet 2017, PMID:28714975. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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