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Who was studied 380 African American cases, 2,129 African American controls, 599 European American cases, 7,327 European American controls; replicated in 233 African American cases, 4,038 African American controls.
The effect
Each copy of the G allele carried 2.29 times the odds of Paediatric migraine (95% confidence interval 1.728-3.046); p = 1 × 10−8.
How common The G allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 5, band 5q33.1 — in an intron of NMUR2.
What each result means
G/GTwo copies of the version the research linked to Paediatric migraine. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Paediatric migraine. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Paediatric migraine. This is the starting point the study compared everyone against.
Journal of medical genetics · 2018 · PMID 30266756
Questions about rs1946225
What is rs1946225?
rs1946225 is a single position in the genome, in or near the NMUR2 gene. Published research associates it with paediatric migraine. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1946225 linked to?
On MyGeneLog this position is linked to Migraine. The research behind each link, and its sources, are set out on that condition page.
Does having rs1946225 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1946225 come from?
GWAS Catalog, J Med Genet 2018, PMID:30266756. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 3837123220Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity3Meta AI7Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others20Total38Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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