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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 324,851 European ancestry individuals, 21,962 South Asian ancestry individuals; replicated in up to 275,596 European ancestry individuals.
The effect
The reported allele is G; the catalogue records no effect size
; p = 1 × 10−9.
How common The G allele had a frequency of about 30% in the people studied.
Where it sits Chromosome 1, band 1p31.3 — in an intron of PDE4B.
What each result means
A/ANo copy of the version the research linked to Smoking initiation. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Smoking initiation. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Smoking initiation. That is the strongest link of the three results. A link in a study is not a diagnosis.
Molecular psychiatry · 2020 · PMID 30617275 · open access
Questions about rs1937455
What is rs1937455?
rs1937455 is a single position in the genome, in or near the PDE4B gene. Published research associates it with smoking initiation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1937455 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1937455 come from?
GWAS Catalog, Mol Psychiatry 2019, PMID:30617275. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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