Standard
Smoking initiation (ever regular vs never regular)
PDE4B · rs1937443
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Smoking initiation (ever regular vs never regular) — no copies of the reported risk allele.
C/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Smoking initiation (ever regular vs never regular).
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Smoking initiation (ever regular vs never regular) compared to the general population.
Source
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Liu M,
Jiang Y,
Wedow R,
Li Y,
Brazel DM,
Chen F,
Datta G,
Davila-Velderrain J,
McGuire D,
Tian C,
Zhan X,
Choquet H
and 111 more — show all
Docherty AR,
Faul JD,
Foerster JR,
Fritsche LG,
Gabrielsen ME,
Gordon SD,
Haessler J,
Hottenga JJ,
Huang H,
Jang SK,
Jansen PR,
Ling Y,
Mägi R,
Matoba N,
McMahon G,
Mulas A,
Orrù V,
Palviainen T,
Pandit A,
Reginsson GW,
Skogholt AH,
Smith JA,
Taylor AE,
Turman C,
Willemsen G,
Young H,
Young KA,
Zajac GJM,
Zhao W,
Zhou W,
Bjornsdottir G,
Boardman JD,
Boehnke M,
Boomsma DI,
Chen C,
Cucca F,
Davies GE,
Eaton CB,
Ehringer MA,
Esko T,
Fiorillo E,
Gillespie NA,
Gudbjartsson DF,
Haller T,
Harris KM,
Heath AC,
Hewitt JK,
Hickie IB,
Hokanson JE,
Hopfer CJ,
Hunter DJ,
Iacono WG,
Johnson EO,
Kamatani Y,
Kardia SLR,
Keller MC,
Kellis M,
Kooperberg C,
Kraft P,
Krauter KS,
Laakso M,
Lind PA,
Loukola A,
Lutz SM,
Madden PAF,
Martin NG,
McGue M,
McQueen MB,
Medland SE,
Metspalu A,
Mohlke KL,
Nielsen JB,
Okada Y,
Peters U,
Polderman TJC,
Posthuma D,
Reiner AP,
Rice JP,
Rimm E,
Rose RJ,
Runarsdottir V,
Stallings MC,
Stančáková A,
Stefansson H,
Thai KK,
Tindle HA,
Tyrfingsson T,
Wall TL,
Weir DR,
Weisner C,
Whitfield JB,
Winsvold BS,
Yin J,
Zuccolo L,
Bierut LJ,
Hveem K,
Lee JJ,
Munafò MR,
Saccone NL,
Willer CJ,
Cornelis MC,
David SP,
Hinds DA,
Jorgenson E,
Kaprio J,
Stitzel JA,
Stefansson K,
Thorgeirsson TE,
Abecasis G,
Liu DJ,
Vrieze S
Nature genetics · 2019 · PMID 30643251 · open access
Questions about rs1937443
What is rs1937443?
rs1937443 is a single position in the genome, in or near the PDE4B gene. Published research associates it with smoking initiation (ever regular vs never regular). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1937443 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1937443 come from?
GWAS Catalog, Nat Genet 2019, PMID:30643251. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants