Sensitive

Kidney stone disease

near ALPL · rs1936824

Where this position leads

Condition: Urolithiasis

rs1936824 Condition: Urolithiasis Urolithiasis Condition rs1936824 rs1936824 near ALPL

What the study found

Who was studied 13,746 East Asian ancestry cases, 241,425 East Asian ancestry controls, 17,969 European ancestry cases, 702,230 European ancestry controls.

The effect Each copy of the A allele carried 1.13 times the odds of Kidney stone disease (95% confidence interval 1.11-1.16); p = 5 × 10−32.

How common The A allele had a frequency of about 26% in the people studied.

Where it sits Chromosome 1, band 1p36.12 — between genes, 6.3 kb from ALPL.

What each result means

A/A Two copies of the version the research linked to Kidney stone disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Kidney stone disease. That is a smaller link than two copies.
G/G No copy of the version the research linked to Kidney stone disease. This is the starting point the study compared everyone against.
Source

Questions about rs1936824

What is rs1936824?

rs1936824 is a single position in the genome, in or near the near ALPL gene. Published research associates it with kidney stone disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1936824 linked to?

On MyGeneLog this position is linked to Urolithiasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs1936824 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1936824 come from?

GWAS Catalog, Nature communications 2025, PMID:40216741. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Kidney stone disease (rs1936824). MyGeneLog™. https://www.mygenelog.com/variants/rs1936824

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