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Who was studied 12,019 European ancestry cases, 1,869,646 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.394 higher (95% confidence interval 0.27-0.52); p = 6 × 10−10.
How common The C allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 6, band 6p21.31 — in an intron of RPS10-NUDT3.
What each result means
C/CTwo copies of the version the research linked to Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Graves' disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Graves' disease. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 41644669 · open access
Questions about rs193135027
What is rs193135027?
rs193135027 is a single position in the genome, in or near the RPS10-NUDT3 gene. Published research associates it with graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs193135027 linked to?
On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs193135027 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs193135027 come from?
GWAS Catalog, Nature genetics 2026, PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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