Sensitive

A disintegrin and metalloproteinase with thrombospondin motifs 13 levels

near ABO · rs1927311

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10⁻²², with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 2,935 Qatari ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.277 lower (95% confidence interval 0.22-0.33); p = 1 × 10⁻²².

How common The T allele had a frequency of about 33% in the people studied.

Where it sits Chromosome 9, band 9q34.2 — between genes, 6.9 kb from ABO.

What each result means

C/C No copy of the version the research linked to A disintegrin and metalloproteinase with thrombospondin motifs 13 levels. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to A disintegrin and metalloproteinase with thrombospondin motifs 13 levels. That is a smaller link than two copies.

T/T Two copies of the version the research linked to A disintegrin and metalloproteinase with thrombospondin motifs 13 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations

Thareja G, Belkadi A, Arnold M, Albagha OME, Graumann J, Schmidt F, Grallert H, Peters A, Gieger C, Consortium TQGPR, Suhre K

Human molecular genetics · 2023 · PMID 36168886 · open access

Questions about rs1927311

What is rs1927311?

rs1927311 is a single position in the genome, in or near the near ABO gene. Published research associates it with a disintegrin and metalloproteinase with thrombospondin motifs 13 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1927311 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1927311 come from?

GWAS Catalog, Human molecular genetics 2023, PMID:36168886. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

A disintegrin and metalloproteinase with thrombospondin motifs 13 levels (rs1927311). MyGeneLog™. https://www.mygenelog.com/variants/rs1927311

← See all variants