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CTSC protein levels

near FOLH1B · rs192642478

Where this position leads

Condition: Celiac Disease

rs192642478 Condition: Celiac Disease Celiac Disease Condition rs192642478 rs192642478 near FOLH1B

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.64 higher (95% confidence interval 0.45-0.83); p = 1 × 10−12.

How common The C allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 11, band 11q14.3 — between genes, 15.8 kb from FOLH1B.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of CTSC protein levels compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with CTSC protein levels.
T/T Published research associates this genotype with typical/baseline likelihood of CTSC protein levels — no copies of the reported risk allele.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs192642478

What is rs192642478?

rs192642478 is a single position in the genome, in or near the near FOLH1B gene. Published research associates it with ctsc protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs192642478 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs192642478 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs192642478 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

CTSC protein levels (rs192642478). MyGeneLog™. https://www.mygenelog.com/variants/rs192642478

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